Pharmacokinetics: ADME
Absorption, Distribution, Metabolism & Excretion — from membrane transport to clearance, kinetics and model-informed dosing
Past RGUHS + DNB + MPMSU + MUHS · 239
RGUHSSep '25
RGUHSMay '25
DNBDec '25
DNBDec '25
DNBDec '25
DNBDec '25
DNBDec '25
DNBJun '25
MUHSWinter '25
MUHSWinter '25
RGUHSSep '25
MPMSUOct '25
MPMSUMay '25
MPMSUJan '25
MPMSUJan '25
MPMSUOct '25
MPMSUMay '25
MPMSUOct '25
MPMSUMay '25
RGUHSSep '25
RGUHSMay '25
RGUHSJun '24
RGUHSJun '24
DNBMay '24
DNBMay '24
DNBOct '24
DNBOct '24
MUHSWinter '24
MUHSWinter '24
RGUHSJun '24
RGUHSDec '23
RGUHSJul '23
DNBApr '23
DNBApr '23
DNBApr '23
DNBApr '23
DNBApr '23
DNBApr '23
DNBOct '23
DNBOct '23
DNBOct '23
DNBOct '23
DNBOct '23
MUHSSummer '23
MUHSSummer '23
MUHSWinter '23
MUHSWinter '23
MUHSWinter '23
RGUHSDec '23
RGUHSJul '23
MPMSUJun '23
MPMSUJun '23
MPMSUJun '23
MPMSUJun '23
RGUHSNov '22
RGUHSNov '22
RGUHSMay '22
DNBDec '22
DNBJun '22
DNBJun '22
DNBJun '22
DNBJun '22
DNBJun '22
MUHSSummer '22
MUHSSummer '22
MUHSSummer '22
RGUHSNov '22
RGUHSMay '22
MPMSU2022
RGUHSMay '22
RGUHSNov '21
RGUHSJul '21
RGUHSJul '21
RGUHSJul '21
DNBDec '21
DNBDec '21
DNBDec '21
DNBDec '21
DNBJun '21
DNBJun '21
DNBJun '21
DNBJun '21
MUHSWinter '21
MPMSUAug '21
MPMSUAug '21
MPMSUAug '21
RGUHSNov '21
RGUHSNov '20
RGUHSJun '20
RGUHSJun '20
DNBDec '20
DNBDec '20
DNBDec '20
DNBDec '20
DNBJun '20
DNBJun '20
DNBJun '20
MUHSSummer '20
MUHSWinter '20
MPMSU2020
RGUHSNov '20
RGUHSJun '20
RGUHSJun '20
RGUHSNov '19
RGUHSNov '19
RGUHSMay '19
RGUHSMay '19
MUHSSummer '19
MUHSSummer '19
MUHSWinter '19
MUHSWinter '19
RGUHSMay '19
MPMSUMay '19
MPMSU2019
MPMSUMay '19
MPMSU2019
RGUHSNov '19
RGUHSMay '19
RGUHSMay '19
RGUHSNov '18
RGUHSMay '18
RGUHSMay '18
MUHSSummer '18
MUHSWinter '18
RGUHSNov '18
MPMSU2018
MPMSUMay '18
MPMSU2018
RGUHSNov '17
RGUHSNov '17
RGUHSNov '17
MUHSSummer '17
MUHSSummer '17
MUHSSummer '17 Suppl
MUHSSummer '17 Suppl
MPMSUJun '17
MPMSU2017
MPMSU2017
MPMSU2017
MPMSU2017
RGUHSNov '16
RGUHSNov '16
RGUHSNov '16
RGUHSNov '16
RGUHSJun '16
DNBDec '16
DNBDec '16
DNBDec '16
DNBDec '16
DNBDec '16
MPMSU2016
MPMSU2016
DNBDec '15
DNBDec '15
DNBDec '15
DNBDec '15
DNBDec '15
MUHSWinter '15
MUHSWinter '15
MUHSWinter '15
MPMSU2015
MPMSU2015
MPMSU2015
DNBDec '14
DNBDec '14
DNBDec '14
DNBDec '14
DNBDec '14
MUHSWinter '14
MPMSU2014
DNBDec '13
DNBDec '13
DNBDec '13
MPMSU2013
DNBDec '12
DNBDec '12
DNBDec '12
RGUHSMay '11
RGUHSMay '11
RGUHSMay '11
RGUHSMay '11
DNBDec '11
DNBDec '11
DNBDec '11
MPMSU2011
MPMSU2011
MPMSU2011
MPMSU2011
RGUHSMay '11
RGUHSOct '10
RGUHSMay '10
RGUHSMay '10
RGUHSMay '10
RGUHSMay '10
RGUHSOct '10
RGUHSMay '10
MPMSU2010
MPMSU2010
MPMSU2010
MPMSU2010
RGUHSMay '10
RGUHSOct '09
RGUHSOct '09
RGUHSOct '09
RGUHSOct '09
RGUHSOct '09
RGUHSMay '09
RGUHSMay '09
RGUHSMay '09
RGUHSMay '09
RGUHSOct '09
MPMSU2009
MPMSU2009
RGUHSOct '09
RGUHSMay '09
RGUHSOct '08
RGUHSOct '08
RGUHSOct '08
RGUHSApr '08
RGUHSApr '08
RGUHSApr '08
RGUHSSep '07
RGUHSApr '07
RGUHSApr '07
MPMSU2007
MPMSU2007
RGUHSApr '07
RGUHSSep '06
RGUHSSep '06
RGUHSSep '06
RGUHSApr '06
MPMSU2006
MPMSU2006
MPMSU2006
RGUHSApr '06
MPMSU2005
MPMSU2005
MPMSU2004
MPMSU1995
Introduction & the ADME framework
- Pharmacokinetics — the quantitative study of drug movement into, through and out of the body — what the body does to the drug, as distinct from pharmacodynamics (what the drug does to the body).
- ADME / LADME — the four PK processes — Absorption, Distribution, Metabolism, Excretion; metabolism + excretion together = elimination. Liberation (L) of drug from the dosage form precedes absorption and is rate-limiting for solid oral forms.
- Clinical relevance — PK governs route, dose, latency of onset, time to peak, duration of action and dosing frequency; response tracks drug concentration at the site of action, which usually mirrors plasma concentration.
- Molecular determinants — movement and availability depend on molecular size, degree of ionization, lipid solubility of the ionized vs nonionized forms, structure and protein binding; every ADME step requires crossing biological membranes.
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Pharmacokinetics Adme
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