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MD Pharmacology NMC syllabus ~5 min read Recent advances last updated on 2026-07-01

Ethanol and Alcohols

Ethanol pharmacokinetics (zero-order ADH/ALDH metabolism, inducible MEOS/CYP2E1) & pharmacodynamics · acute intoxication & its management · chronic use — tolerance, dependence & withdrawal (tremors → seizures → delirium tremens) · pharmacotherapy of alcohol use disorder (disulfiram, naltrexone, acamprosate, baclofen) · the disulfiram-like reaction & drug interactions · toxic alcohols — methanol & ethylene-glycol poisoning (fomepizole, ethanol antidote, haemodialysis) · Indian context

Introduction & chemistry

  • Definition — alcohols are hydroxy (–OH) derivatives of aliphatic hydrocarbons; unqualified, "alcohol" means ethyl alcohol / ethanol (CH3CH2OH), a 2-carbon alcohol rapidly distributed into body water and brain.
  • Public-health scale — ethanol is the oldest recreational drug and likely causes more morbidity, mortality and cost than all illicit drugs combined; its pharmacological importance is in beverages, alcoholism and intoxication, not as a medicine.
  • Alcohol use disorder (AUD) — DSM-5 merges "abuse" and "dependence" into a single AUD on a mild–moderate–severe continuum (≥2 of 11 behaviours/12 months; mild 2–3, moderate 4–5, severe 6–11) across four domains — impaired control, social consequences, risky use, altered physiology (tolerance/withdrawal). Heritability 50–60%.
  • Beverages & forms — made by fermentation of sugars (self-limiting at ~15%); Indian licensed spirits standardised to 42.8% v/v (37% w/w), chiefly from molasses. Other forms: absolute alcohol (99% w/w), rectified spirit (90%), proof spirit (57.1% v/v), and methylated/denatured (industrial) spirit = rectified spirit + 5% wood naphtha (methanol), tinted blue to render it undrinkable.
  • Standard drink — a US standard drink (12 oz beer / 5 oz wine / 1.5 oz shot) ≈ 14 g ethanol; "proof" = twice the % alcohol. Indian "1 drink" (KDT) = 50 mL spirits ≈ 16 g → peak BEC ~30 mg/dL on an empty stomach.
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Ethanol And Alcohols

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