Aminoglycosides
Mechanism, Pharmacokinetics, Resistance & Clinical Use
Past RGUHS + MPMSU + MUHS · 10
MPMSUJan '25
RGUHSNov '21
MUHSSummer '21
RGUHSNov '20
MUHSSummer '20
RGUHSMay '18
MUHSSummer '17
RGUHSJun '16
RGUHSMay '10
RGUHSSep '07
- Natural and semisynthetic bactericidal antibiotics — amino sugars glycosidically linked to a central aminocyclitol ring (streptidine in streptomycin; 2-deoxystreptamine in all others).
- Produced by soil actinomycetes — Streptomyces spp. yield the -mycin suffix (streptomycin, neomycin, tobramycin); Micromonospora spp. yield -micin (gentamicin, sisomicin); semisynthetic — amikacin, netilmicin, plazomicin, arbekacin.
- Prototype concentration-dependent bactericidals with a prominent post-antibiotic effect (PAE) AND prototype narrow-therapeutic-index drugs requiring therapeutic drug monitoring.
- Active mainly against aerobic Gram-negative bacilli (incl. Pseudomonas aeruginosa); no anaerobic activity; synergistic with cell-wall-active agents against Gram-positive cocci (Enterococcus, Streptococcus).
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Aminoglycosides
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