Pharmacokinetics: ADME
Absorption, Distribution, Metabolism & Excretion — from membrane transport to clearance, kinetics and model-informed dosing
Past RGUHS + DNB + MPMSU + MUHS · 239
RGUHSSep '25
RGUHSMay '25
DNBDec '25
DNBDec '25
DNBDec '25
DNBDec '25
DNBDec '25
DNBJun '25
MUHSWinter '25
MUHSWinter '25
RGUHSSep '25
MPMSUOct '25
MPMSUMay '25
MPMSUJan '25
MPMSUJan '25
MPMSUOct '25
MPMSUMay '25
MPMSUOct '25
MPMSUMay '25
RGUHSSep '25
RGUHSMay '25
RGUHSJun '24
RGUHSJun '24
DNBMay '24
DNBMay '24
DNBOct '24
DNBOct '24
MUHSWinter '24
MUHSWinter '24
RGUHSJun '24
RGUHSDec '23
RGUHSJul '23
DNBApr '23
DNBApr '23
DNBApr '23
DNBApr '23
DNBApr '23
DNBApr '23
DNBOct '23
DNBOct '23
DNBOct '23
DNBOct '23
DNBOct '23
MUHSSummer '23
MUHSSummer '23
MUHSWinter '23
MUHSWinter '23
MUHSWinter '23
RGUHSDec '23
RGUHSJul '23
MPMSUJun '23
MPMSUJun '23
MPMSUJun '23
MPMSUJun '23
RGUHSNov '22
RGUHSNov '22
RGUHSMay '22
DNBDec '22
DNBJun '22
DNBJun '22
DNBJun '22
DNBJun '22
DNBJun '22
MUHSSummer '22
MUHSSummer '22
MUHSSummer '22
RGUHSNov '22
RGUHSMay '22
MPMSU2022
RGUHSMay '22
RGUHSNov '21
RGUHSJul '21
RGUHSJul '21
RGUHSJul '21
DNBDec '21
DNBDec '21
DNBDec '21
DNBDec '21
DNBJun '21
DNBJun '21
DNBJun '21
DNBJun '21
MUHSWinter '21
MPMSUAug '21
MPMSUAug '21
MPMSUAug '21
RGUHSNov '21
RGUHSNov '20
RGUHSJun '20
RGUHSJun '20
DNBDec '20
DNBDec '20
DNBDec '20
DNBDec '20
DNBJun '20
DNBJun '20
DNBJun '20
MUHSSummer '20
MUHSWinter '20
MPMSU2020
RGUHSNov '20
RGUHSJun '20
RGUHSJun '20
RGUHSNov '19
RGUHSNov '19
RGUHSMay '19
RGUHSMay '19
MUHSSummer '19
MUHSSummer '19
MUHSWinter '19
MUHSWinter '19
RGUHSMay '19
MPMSUMay '19
MPMSU2019
MPMSUMay '19
MPMSU2019
RGUHSNov '19
RGUHSMay '19
RGUHSMay '19
RGUHSNov '18
RGUHSMay '18
RGUHSMay '18
MUHSSummer '18
MUHSWinter '18
RGUHSNov '18
MPMSU2018
MPMSUMay '18
MPMSU2018
RGUHSNov '17
RGUHSNov '17
RGUHSNov '17
MUHSSummer '17
MUHSSummer '17
MUHSSummer '17 Suppl
MUHSSummer '17 Suppl
MPMSUJun '17
MPMSU2017
MPMSU2017
MPMSU2017
MPMSU2017
RGUHSNov '16
RGUHSNov '16
RGUHSNov '16
RGUHSNov '16
RGUHSJun '16
DNBDec '16
DNBDec '16
DNBDec '16
DNBDec '16
DNBDec '16
MPMSU2016
MPMSU2016
DNBDec '15
DNBDec '15
DNBDec '15
DNBDec '15
DNBDec '15
MUHSWinter '15
MUHSWinter '15
MUHSWinter '15
MPMSU2015
MPMSU2015
MPMSU2015
DNBDec '14
DNBDec '14
DNBDec '14
DNBDec '14
DNBDec '14
MUHSWinter '14
MPMSU2014
DNBDec '13
DNBDec '13
DNBDec '13
MPMSU2013
DNBDec '12
DNBDec '12
DNBDec '12
RGUHSMay '11
RGUHSMay '11
RGUHSMay '11
RGUHSMay '11
DNBDec '11
DNBDec '11
DNBDec '11
MPMSU2011
MPMSU2011
MPMSU2011
MPMSU2011
RGUHSMay '11
RGUHSOct '10
RGUHSMay '10
RGUHSMay '10
RGUHSMay '10
RGUHSMay '10
RGUHSOct '10
RGUHSMay '10
MPMSU2010
MPMSU2010
MPMSU2010
MPMSU2010
RGUHSMay '10
RGUHSOct '09
RGUHSOct '09
RGUHSOct '09
RGUHSOct '09
RGUHSOct '09
RGUHSMay '09
RGUHSMay '09
RGUHSMay '09
RGUHSMay '09
RGUHSOct '09
MPMSU2009
MPMSU2009
RGUHSOct '09
RGUHSMay '09
RGUHSOct '08
RGUHSOct '08
RGUHSOct '08
RGUHSApr '08
RGUHSApr '08
RGUHSApr '08
RGUHSSep '07
RGUHSApr '07
RGUHSApr '07
MPMSU2007
MPMSU2007
RGUHSApr '07
RGUHSSep '06
RGUHSSep '06
RGUHSSep '06
RGUHSApr '06
MPMSU2006
MPMSU2006
MPMSU2006
RGUHSApr '06
MPMSU2005
MPMSU2005
MPMSU2004
MPMSU1995
Pharmacokinetics: ADME
1. Definition, scope, and the ADME framework
- Pharmacokinetics (PK) is the quantitative study of drug movement into, through, and out of the body — "what the body does to the drug" — as distinct from pharmacodynamics ("what the drug does to the body") (KDT 8e Ch.2, pp.15–16).
- The four processes of pharmacokinetics are Absorption, Distribution, Metabolism, and Excretion — collectively ADME; metabolism + excretion together constitute elimination (G&G 14e Ch.2, pp.23–24).
- Some texts prepend Liberation (release of drug from its dosage form) → LADME; liberation is rate-limiting for solid oral dosage forms where dissolution precedes absorption (G&G 14e Ch.2, p.25; KDT 8e Ch.2, p.21).
- Clinical relevance: PK parameters determine the route, dose, latency of onset, time of peak action, duration of action, and dosing frequency of a drug (KDT 8e Ch.2, p.15).
- The intensity and duration of response are governed by drug concentration at the site of action, which is itself a function of the drug's disposition; in most cases this tracks the systemic (plasma) concentration (G&G 14e Ch.2, pp.23, 42).
- The molecular determinants of a drug's movement and availability at its site of action are: molecular size (MW), degree of ionization, lipid solubility of the ionized vs nonionized forms, structural features, and protein binding (G&G 14e Ch.2, p.23).
- All four ADME processes require the drug to traverse one or more biological membranes; the plasma membrane is the basic barrier (G&G 14e Ch.2, p.23).
- Goal of applying PK principles: increase probability of therapeutic success while reducing adverse drug events and drug–drug interactions (G&G 14e Ch.2, p.23).
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Pharmacokinetics Adme
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